>> Sophora Japonica
1. Active constituents from Sophorajaponica exhibiting cellular tyrosinase inhibition in human epidermal melanocytes.
Yuan-Hsin Loa, Rong-Dih Linb, c, Yi-Pei Lind, e, Yan-Ling Liue, Mei-Hsien Lee. Volume 124, Issue 3, 30 July 2009, Pages 625–629.
"There is greater consumer awareness of plant-based skin-care products. Sophorajaponica L. (Fabaceae) has been used traditionally as
a hemostatic agent and also has skin-care and whitening benefits. The effect of the isolated active compounds of Sophorajaponica L.
(Fabaceae) that inhibits tyrosinase activity in human epidermal melanocytes (HEMn) was examined."
2. The Use Of Rutin In Anti-aging Cosmetics.
"With the use restrictions on the synthetic chemicals, environmental has become the developing direction of cosmetics in the 21st century. The
nature characteristic of cosmetic materials gets increasing attentions. The development of natural cosmetics has become a trend.
The rutin extracting from sophora japonica has the functions of anti-bacterial, anti-inflammatory and anti-radiation just like vitamin P. It can
regulate the capillary wall permeation, reduce vascular fragility and becomes a treatment of atopic dermatitis. It can be made into glutathione
creams and lotions cosmetics for sunscreen, freckle, acne and underarm odor."
3. Active constituents from Sophora japonica exhibiting cellular tyrosinase inhibition in human epidermal melanocytes.
Lo YH, Lin RD, Lin YP, et al. Department of Dermatology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 111, Taiwan. J Ethnopharmacol
2009 Jul 30; 124(3) :625-9.
"There is greater consumer awareness of plant-based skin-care products. Sophora japonica L. (Fabaceae) has been used traditionally
as a hemostatic agent and also has skin-care and whitening benefits. The effect of the isolated active compounds of Sophora japonica L.
(Fabaceae) that inhibits tyrosinase activity in human epidermal melanocytes (HEMn) was examined.We used the mushroom tyrosinase inhibitory
assay to isolate active constituents from the extracts. The structures of these constituents were characterized by physical and spectroscopic
analyses. Cellular tyrosinase kinetics were analyzed and showed by Lineweaver-Burk plot.A new compound, N-feruloyl-N'-cis-feruloyl-
putrescine (8), together with four flavonoids and three putrescine derivatives were obtained after assay-guided isolation of S. japonica. In
HEMn, compound 8 was minimally cytotoxic (cell viability >90% at 100 microM) and the IC(50) value for suppression of cellular tyrosinase activity
was estimated as 85.0 microM. Zymography analysis demonstrated the compound's concentration-dependent effects and the kinetic analysis
indicated the compound's mixed-inhibitory action.We concluded that the new compound 8 is the most potent component of S. japonica yet
discovered. Its pigment inhibition activity may be exploitable cosmetically."