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    Cucumis Sativus

    1. Inhibitory effect of Cucumis sativus on melanin production in melanoma B16 cells by downregulation of tyrosinase expression.
    Kai H, Baba M, Okuyama T. Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University, Tokyo, Japan. Epub 2008 Nov 13.

    "We compared the inhibitory effects on melanogenesis of six plant parts (leaves, stems, roots, whole fruits, calyxes, and fruits without calyxes) of Cucumis sativus. MeOH extracts of leaves and stems inhibited melanin production in B16 cells. These extracts did not affect the activity of mushroom tyrosinase or crude enzyme lysate from B16 cells. However, the extracts decreased tyrosinase expression at the protein level. These results suggest that the depigmenting mechanism of extracts from leaves and stems of C. SATIVUS involves the expression of tyrosinase. Of eight compounds isolated from the leaves, lutein ( 1) (IC (50) = 170.7 microM) and (+)-(1 R,2 S,5 R,6 S)-2,6-di-(4'-hydroxyphenyl)-3,7-dioxabicyclo[3.3.0]octane ( 2) (IC (50) = 270.8 microM) were found to suppress melanogenesis. Whereas 1 was found to markedly decrease the expression levels of tyrosinase, 2 only weakly reduced tyrosinase expression. This suggests that 1 is an active component in the leaves of C. sativus and is a potentially useful skin-whitening agent."

    2. The Best Skin Lighteners For Your Skin.
    Jean Helmet, submitted on December 8, 2008.

    "There are some other natural ingredients you should look for. They are: Cucumis Sativus, Caraway Extract, Carrot seed extract, Paraffinum Liquid, Geranium, Ginseng Extract, and Proprietary Complex etc. They are very much effective ingredients that the top quality skin lighteners are made from."

    3. Information About Skin Care Lighteners And Hyper-Pigmentation.
    By Kristi Ambrose, Nov 25, 2008.

    "Vital ingredients in the compounded formulation light up the general color of the skin by heightening blood & oxygen circulation and cell metabolism. These newfound pigment-lightening formulas prohibits melanin formation which represses the appearance of hyper pigmentation, skin discoloration, and uneven skin tone on the face with noticeable effects within just a few days time. So you could literally start using it at the beginning of the work week and you will start seeing results the next Monday after that. Pretty innovative stuff if you ask me! I think the best part about these products aren't the results, I think its the ingredients. .... These products usually will include things like; Ginseng Extract, Caraway Extract, Carrot Seed Extract, Geranium, Limonium, Cucumis Sativus, Paraffinum Liquid, Proprietary Whitening Complex, Natural Fragrance. So all in all it really is good for your skin, healthy, and it doesn't contain a ton of chemicals!"