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    Angelica Dahurica

    1. New cosmetic agents for skin whitening from Angelica dahurica.
    Cho YH, Kim JH, Park SM, Lee BC, Pyo HB, Park HD. R&D Center, Hanbul Cosmetic Corporation, 72-7 Yongsung-ri, Samsung-myun, Umsung-kun, Chungbuk 369-834, Korea. 2006 Jan-Feb.

    "To develop a new whitening agent for cosmetics from natural products, Angelica dahurica was selected for its inhibitory effect on melanogenesis in B16 melanoma cells. From the mechanism study, it was clarified that the ethanolic extracts of this plant showed the suppression of tyrosinase synthesis but no inhibition of tyrosinase activity. In order to find the active constituents from this plant, the ethanol extracts were chromatographed repeatedly with silica gel. Two coumarin compounds were isolated from A. dahurica. Their structures were identified by physicochemical and spectral data such as UV, IR, NMR, and MS. It was shown that the active substance was isoimperatorin and imperatorin. They significantly inhibited tyrosinase synthesis in B16 melanoma cells. To elucidate the action mechanism of the active compounds of A. dahurica, we investigated the changes in the mRNA level of tyrosinase using the RT-PCR technique. As a result, the mRNA level of tyrosinase was markedly reduced by active compounds of A. dahurica. From these results, we suggest that these extracts might be useful as a new whitening agent in cosmetics, but the in vitro findings must be verified in in vivo skin-lightening studies."

    2. Study Progress and Prospects on the Comprehensive Exploitation of Angelica dehurica.
    JIANG Gui-hua,ZHANG Lv-ming,MA Yu-ying,CHEN Su-lan,WU Yuan-yuan(Chengdu University of TCM,Chengdu 611730,China.

    "Angelica dahurica is one of medicinal material of our country in common use.This paper discusses the analgesic effect of Angelica dahurica,including relieving pain,curing medical value such as rhinitis,pharyngitis,vitiligo,psoriasis and empyrosis and its function of skin whitening,driving away speckle and reducing weight in the field of cosmetology and beautifying body.It can also be used as the condiment and spice,or be used in the food and the livestock industry.We also analyze the prospect of comprehensive development and utilization angelica dahurica's in order to provide reference for its exploitation."

    3. Anti-inflammatory activity of Angelica dahurica ethanolic extract on RAW264.7 cells via upregulation of heme oxygenase-1.
    Lee MY, Lee JA, Seo CS, Ha H, Lee H, Son JK, Shin HK. Herbal Medicine EBM Research Center, Korea Institute of Oriental Medicine, Exporo 483, Yusung-gu, Daejeon 305-811, Republic of Korea. Epub 2011 Jan 25.

    "In this study, we analyzed the anti-inflammatory effects of Angelica dahurica Bentham et Hooker ethanolic extract (ADEE) on RAW264.7 cells, to understand the mechanism underlying its observed effects. ADEE inhibited cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, leading to the suppression of COX-2-derived prostaglandin E(2) and iNOS-derived production in lipopolysaccharide (LPS)- stimulated RAW264.7 cells. These inhibitory effects of ADEE were accompanied by the reduced production of tumor necrosis factor alpha and interleukin (IL)-6. ADEE also inhibited nuclear factor KB (NFKB) translocation to the nucleus by interrupting inhibitor kappa Balpha degradation. ADEE upregulated heme oxygenase 1 expression, and treatment with tin protoporphyrin IX (SnPP), a selective inhibitor of HO-1, reversed the LPS-induced generation of proinflammatory cytokines. ADEE also induced IL-4 and IL-5 expression in concanavalin-A-stimulated splenocytes. These results suggest that ADEE has anti-inflammatory activity, which acts via the suppression of the NF-KB pathway."