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    Alpinia Officinarum

    1. Antiaging Chirally-Correct Mitoprotectant Amino Acid and Peptide Complexes.
    Shyam K.Gupta, Scottsdale, AZ (US); Linda Walker, Cardiff, CA (US). Shyam K.Gupta Bioderm Research 5221 E. Windrose Drive Scottsdale, AZ 85254 (US). Pub.Date:Dec.30,2010.

    "Anti-inflammatory agents are required in the present invention to reduce the skin irritation caused by environmental, personal hygiene, body beautification, and dietary/personal habits situations. It is to be noted that a mixture of two or more anti-inflammatory agents, especially those that belong to different biochemical mechanism classes, is more beneficial than corresponding equal weight amounts of a single ingredient. This is due to various different biochemical mechanisms by which such anti-inflammatory agents provide their beneficial effect. A number of both synthetic and natural agents have thus become available; some of such examples follow (the biochemical mechanisms of their action are indicated in the parenthese). Ginger Root, or Zingiber Officinale Root Extract (COX-2 inhibitor), Galanga, or Alpinia Officinarum Extract (LOX-5 inhibitor),"

    2. Mechanism and inhibitory effect of galangin and its flavonoid mixture from Alpinia officinarum on mushroom tyrosinase and B16 murine melanoma cells.
    Lu YH, Lin Tao, Wang ZT, Wei DZ, Xiang HB.State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, Shanghai 200237, PR China.2007 Aug;22.

    "The whitening effects of the flavonoid constituents of Alpinia officinarum Hance were investigated on melanin biosynthesis in B 16 mouse melanoma cells, tyrosinase inhibition and UV absorption. The melanin content was reduced to 1.276 microg /10(5) cell for flavonoid mixture and 1.161 microg /10(5) cell for galangin while the melanin control was 1.632 microg/10(5) cell. Both flavonoid mixture and galangin reduced melanin production with an inhibition of 21.81% and 28.86% at a concentration of 26.5 microg/mL and 29 microg/mL (107.4 microM), respectively. Tyrosinase inhibition by the flavonoid mixture and galangin were higher at lower concentrations and galangin showed competitive inhibition at a concentration less than 21.23 microg/mL which was soluble. In addition, the flavonoid mixture and galangin showed a broad absorption band at 270 approximately 290 nm related to the UV-B area. These observations suggest that galangin may be a whitening agent and a promising candidate for prevention of skin cancer. This is the first full scale report on the evaluation of the whitening effect of galangin."

    3. Ayurvedic anti-aging: ancient medicinal practices have many applications in modern skin care formulations.
    Shyam Gupta. Business Library.

    "Galanga (Alpinia officinarum), also known as Galangal or Chinese ginger, contains essential oils, gingerols and a group of pungent substances, diarylheptanoids. Diarylheptanoids (and analogous phenyl alkyl ketones) possess excellent anti-arthritic properties due to their arrest of prostaglandin biosynthesis via inhibition of 5-lipoxygenase. Kaempferia galanga is easily confused with other members of the ginger family. The medicinal and cosmetic applications of various galanga preparations include sun protection, skin whitening, anti-cancer, larvaecidal and amebicidal, insect repellent, vasorelaxant and MAO-inhibition applications. Purified extracts of galanga, which are composed primarily of lower alkyl cinnamate esters, have UV absorbing, (8) antioxidant and tyrosinase inhibiting properties."