TREATACNEPRONESKIN

Ingredients Glossary A-Z



Highlights





  • Home >> Alpha Arbutin
    Alpha Arbutin

    1. Treatment of refractory dermal melasma with the MedLite C6 Q-switched Nd:YAG laser: Two case reports.
    Kasemrad Aesthetics Center, Kasemrad Hospital Prachacheun, Bangkok, Thailand.


    "Objective: Dermal melasma in Fitzpatrick skin types III–V usually does not respond to topical treatments. Laser resurfacing often either fails to treat these lesions or results in severe postinflammatory hyperpigmentation (PIH) or permanent hypopigmentation. Two cases of refractory dermal melasma are reported, which responded to treatment with the MedLite C6 Q-switched Nd:YAG laser. Methods: Case 1: A 50-year-old Asian female with refractory dermal melasma and severe PIH received 10 weekly laser treatments combined with 7% alpha arbutin and a broad-spectrum sunscreen. Case 2: A 45-year-old Asian female with refractory dermal melasma received 10 weekly laser treatments combined with 7% alpha arbutin and a broad-spectrum sunscreen. Results: In both cases, there was a greater than 80% reduction in epidermal and dermal hyperpigmentation. The melanin index at the site of the lesions decreased from 50 to 35 and 45 to 33, respectively. There was no recurrence of melasma at 1 year (case 1) or 6 months (case 2). Conclusion: Even in cases of long-standing refractory dermal melasma in a darker skin type, combination therapy has been shown to be an effective treatment for this difficult condition."

    2. Treatment of refractory melasma with the MedLite C6 Q-switched Nd:YAG laser and alpha arbutin: A prospective study.
    Kasemrad Aesthetics Center, Kasemrad Hospital Prachacheun, Bangkok, Thailand.


    "Objective: To evaluate the effectiveness of a Q-switched Nd:YAG laser (MedLite C6; HOYA ConBio, Fremont, CA, USA) and 7% alpha arbutin solution (Skin Advance Laboratory, Japan) in the treatment of melasma. Methods: This was a prospective study of 35 refractory melasma cases treated with 10 weekly laser sessions, two monthly follow-up treatments and topical 7% alpha arbutin solution. Clinical photographs and severity grading on a 5-point scale were carried out by an independent observer at each visit. Results: At 6 months, 30% of study subjects received results in the excellent clearance category (> 81% reduction of melasma) and 36.7% received good (51–80% reduction) clearance. Mild and transient side effects included discomfort during treatment, erythema, whitening of fine hair and urticaria. Three cases of mottling hypo-pigmentation (8.57%) and two cases of recurrence of melasma (5.71%) were recorded. Conclusion: Combination therapy with the MedLite C6 and 7% alpha arbutin solution is an effective and well-tolerated treatment for refractory melasma."

    3. Alpha-Arbutin for Skin Whitening.
    health.articles10.com.


    "The product comes in a white powder form that can be dissolved in water. It can withstand pH ranges of 3.6-6.5. When Alpha Arbutin is used in lotion form, a one-percent concentration of this compound can cause a faster rate of lightening with an even lighter skin tone as compared to other similar products. The compound works by blocking the biosynthesis of epidermal melanin which then results in the lighter skin tone. There are a lot of commercial products that come with Alpha Arbutin available these days. They come in the form of whitening creams, lotions, and bleaching serums which are mostly aimed at helping consumers achieve a lighter complexion and reducing skin impurities like erythema and brown age spots."